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An Analysis of the Predictive Ability of Activated Clotting Times During Percutaneous Coronary Interventions for the Incidence of Bleeding Complications

Tiger Du

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School: Revere High School
Internship Track: Laboratory Medicine
Year 2018
Mentor: Margaret Zanin, MS, BSN, RN
Co-Mentor(s): Tonya Frederick, MSN, RN
Department(s): Heart & Vascular Center
Abstract: One way to open blocked or narrowed arteries in the heart is to use a catheter to insert mesh tubes that expand the vessel wall via a procedure called percutaneous coronary intervention (PCI). To ensure that no blood clots, or thrombi, form during the operation, anticoagulants such as heparin are given to the patient intravenuously (through an IV). However, if too much anticoagulant is administered, the patient may be at an increased risk for bleeding complications, such as a dangerous drop in hemoglobin levels. Thus, activated clotting time (ACT) was developed as a relatively expedient blood coagulation test to monitor the effect of anticoagulants during procedure, and its association with subsequent bleeding complications is worth investigating.