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Case-Control Association Analysis of Four SNPs With Atrial Fibrillation

Taejun Kim

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School: Hudson High School
Internship Track: Translational Medicine
Year 2016
Mentor: Qing Wang, PhD
Co-Mentor(s):
Department(s): Molecular Cardiology
Abstract: Genetic factors contribute significantly to the risk of Atrial Fibrillation (AF) . To date, there are 17 genetic loci identified for AF by genome-wide association study (GWAS). We conducted a GWAS for AF in Chinese population and identified 8 SNPs. In this project, we applied Taqman assay to examine associations of 4 SNPs with AF in the Cleveland Clinic AF cohort. One SNP rs2200733 was statistically significantly associated with AF (OR=1.85, P=1.16×10-9). The other 3 SNPs failed in replication. Larger sample are need to confirm such associations.