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Identification of New Genetic Variants Associated With Coronary Artery Disease in African Americans

Taejun Kim

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School: Hudson High School
Internship Track: Translational Medicine
Year 2017
Mentor: Qing Wang, PhD, MBA
Co-Mentor(s): Fan Wang, PhD
Department(s): Department of Molecular Cardiology, Lerner Research Institue
Abstract: In this study, we worked to identify genes causing the risk of coronary artery disease (CAD) in African American populations. Due to the high risk of CAD in the African American population as well as the failure to replicate association studies that were successful in European populations. We chose to study genes that were previously associated with pathologically similar diseases, such as stroke and atrial fibrillation (AF) alongside a couple genes that were associated with CAD in European populations. This study helped to establish that the pathological development of CAD, stroke, and AF may be linked within the function of the gene PTIX2.